The Dutch brewer will kit out the London pubs with banners, posters, beer taps and Olympic-branded glassware, while staff will be kitted out in Heineken-green uniforms.
Heineken is the official lager supplier and sponsor of London 2012. It is a tier three sponsor with exclusive pouring rights for its beer and cider brands at Olympic venues.
Ahead of the start of the Olympics, Heineken is taking over Alexander Palace in North London, which will host the Dutch Olympic Committee during the Games. The site will be called Holland Heineken House.
As part of its sponsorship, Heineken is running a "text to win" competition, offering customers the chance to win tickets to Olympic parties.
Follow John Reynolds on Twitter @johnreynolds10