A spokeswoman confirmed it is likely to affect marketers who hold managerial grade roles, but could not confirm the number of marketers who would lose their jobs.
The job cuts come as part of a "continuous focus on efficiency" that follows the privatisation of the company at the end of last year.
The reduction in marketing staff head count comes despite the Royal Mail launching its first TV ad campaign in six years over Christmas, to promote the dedication of its postmen and women.
Royal Mail claims it will also create around 300 "new or enhanced" roles meaning there will be an overall net reduction of 1,300 jobs.
The company is keen to stress there is no impact on frontline employees, including postmen and women, or the services Royal Mail provides to customers.
Job cuts aim to deliver annual cost savings of around £50m, with the redundancy packages and other associated costs expected to hit £100m.
Moya Greene, chief executive officer at Royal Mail, said: "We are continuously improving our efficiency, whilst maintaining our high quality of service
"We need to do so in order to effectively compete in the letters and parcels markets. This is the best way to ensure the continued delivery of the universal service and the good quality jobs we provide for our people."