OMD and Kitcatt Nohr Alexander Shaw took the media and direct prizes respectively, while AKQA won the digital category.
RKCR/Y&R won the Grand Prix at this year's IPA Effectiveness Awards for its work for Marks & Spencer. The ads it has produced have been central to the recovery of the retailer, whose UK sales rose 10.5% in the six months to September. The company cited the "Your M&S" campaign as a major factor in its revival.
Elsewhere, the agency took the bold move of putting Kate Moss at the heart of Virgin Mobile's ad campaign at a time when other brands were dropping her. It also won a place on the BBC's £20m advertising roster.
OMD, which picked up £78m of new business in 2006, triumphed due to its efforts to innovate. The agency oversaw Vodafone's secret gigs activity and created a blog to back its award-winning Sony Bravia ads.
Kitcatt Nohr's highlights included winning Citroën's direct account and a series of briefs from Norwich Union, while AKQA won global assignments from McDonald's and Smirnoff.
If you have an opinion on this or any other issue raised on Brand Republic, join the debate in the Forum.