Tiffany & Co, Yves Saint Laurent and Mulberry, along with technology brands Samsung and T-Mobile are among the launch advertisers in the centre across the 110 bespoke, 57-inch LCD screens.
Ads will be located in pods around the centre, which are double-sided for maximum visibility. The images will appear in high definition, with each screen linked to a digital advertising network that enables partners to remotely update their messages on a 60-second loop.
The biggest of the three screens, which measures 13 metres by 4.5 metres, will be located above The Atrium, the main event space within Westfield London.
Nicky Cheshire, director of Alive, CBS Outdoor said: 'We believe that our unique digital proposition at Westfield will redefine retail advertising in the UK and bring a host of new advertisers into our market. The high production values, flexibility of targeting and stunning retail environment will offer advertisers a premium platform for captivating some of the capital's most affluent consumers.'