The tie-up will centre on AidMaker, an application to help raise money for charities every time users make an online purchase. Once loaded onto users' profiles it will offer a reminder of which online shops they can donate to charity through.
By shopping online via the charity site at one of 5000 participating stores, which include Amazon and eBay, a proportion of the profit will go directly to charities such as Save the Children, the British Red Cross and Amnesty International.
The partnership will operate across seven countries: the UK, France, Germany, Italy, Holland, Sweden and Denmark.
MySpace promotes social campaigns online through its IMPACT channel, designed to allow politicians, non-profits and civic organisations to connect with the online community.