The annual campaign, which was handled last year by Harvest Digital, will span TV, direct response ads, press and inserts.
MC&C is working with creative agency Watson Phillips & Norman to deliver the DRTV push, following its appointment without a pitch. MC&C will also handle press ads and inserts with design agency Tangible.
The latter element will appear in lifestyle and supplement magazines including The Telegraph magazine, The Big Issue, Radio Times and The Economist.
The DRTV push will run until the New Year on channels including Channel 4, UKTV History and TCM.
Separately, The Salvation Army has launched its annual Christmas present appeal. Last year, the charity collected and distributed more than 150,000 gifts to those in need.
In September, The Salvation Army's charity shops posted a profit increase of 64% to £6.2m over the past year- the biggest growth in the UK charity shop sector.
Projects run by The Salvation Army include homeless centres, drug rehabilitation centres, schools and hospitals.
The charity also supports the emergency services by providing shelter and counselling after disasters.